Did you grow up, as I did, playing "Cowboys and Indians?" (I'm sure that is politically incorrect now.) Of course, in those games, the cowboys soundly routed the Indians.
It turns out that my equally politically incorrect friends and I were wrong, that as early as 1791, Indian warriors, under the command of Chief Tecumesh, won a decisive victory over the colonists.
The battle took place on the east fork of the Wabash River in Ohio. The chief's warriors supprised American soldiers under the command of General St. Clair. Over six hundred Americans were killed, while another 500 ran for their lives in the face of their fierce opponents.